Overview of classic compounds—curated for clinicians and curious minds.
Click on substance name for details. The demo shows only two of the full list available in the full guide.
LSD (Lysergic Acid Diethylamide) is a potent psychedelic discovered by Albert Hofmann in 1943. Known for its long duration and profound consciousness-altering effects, it has been extensively studied for therapeutic applications.
LSD acts as a partial agonist at multiple serotonin receptors, particularly 5-HT2A. It has high binding affinity and slow dissociation, contributing to its extended duration of action (8-12 hours).
Extensive research in the 1950s-60s was halted due to prohibition. Recent studies by MAPS, Imperial College, and other institutions explore applications for anxiety, depression, and PTSD.
Shows promise for anxiety disorders, depression, addiction treatment, and end-of-life distress. May enhance creativity and problem-solving abilities in therapeutic contexts.
Generally physiologically safe but psychologically intense. Risks include anxiety, panic, psychotic episodes in predisposed individuals, and potential for accidents due to altered perception.
LSD therapy requires experienced practitioners and carefully controlled environments. The extended duration necessitates full-day sessions with comprehensive support and integration work.
Mescaline is a phenethylamine psychedelic found in various cacti including peyote and San Pedro. It has been used traditionally for millennia and offers unique therapeutic insights.
Acts primarily at 5-HT2A receptors with additional activity at 5-HT2C and other serotonin receptors. Slower onset and longer duration than tryptamine psychedelics.
Limited modern research due to legal restrictions, but growing interest in its therapeutic potential for depression, anxiety, and spiritual/existential concerns.
Traditional use focuses on healing, divination, and spiritual connection. Modern applications explore depression, anxiety, and nature-disconnection syndromes.
Generally well-tolerated physically. Psychological risks include anxiety, disorientation, and potential for challenging experiences. Long duration requires significant time commitment.
Mescaline therapy often emphasizes connection with nature and traditional indigenous wisdom. The extended duration allows for deep introspective work and integration.